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When the Buffalo Bills match up with the San Francisco 49ers at 8:20 p.m. ET on Sunday, Dec. 1, our projection system predicts the Bills will come out on top. Our model also projects the spead, point total, and final score, which you can see below.
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Bills vs. 49ers Game Info and TV Channel
- When: Sunday, December 1, 2024 at 8:20 p.m. ET
- Where: Highmark Stadium in Orchard Park, New York
- TV: NBC
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Bills vs. 49ers Odds and Betting Info
- Spread favorite: Bills (-6)
- Moneyline: Bills (-265), 49ers (+217)
- Total: 44.5 points
Bills vs. 49ers Prediction
- Pick ATS: Bills (-6)
- Pick OU: Over (44.5)
Prediction:
Bills 31 - 49ers 17
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Bills vs. 49ers Betting Insights
- The Bills are 7-4-0 ATS this season.
- The 49ers have won four games against the spread this year, failing to cover seven times.
- Buffalo has covered the spread once when favored by 6 points or more this season (in three opportunities).
- San Francisco has been an underdog by 6 points or more this season once, and failed to cover the spread.
- Bills games have gone over the point total seven out of 11 times this season.
- In 2024, six 49ers games have hit the over.
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